Metabolic engineering, new antibiotics and biofilm viscoelasticity
نویسندگان
چکیده
منابع مشابه
Metabolic engineering, new antibiotics and biofilm viscoelasticity
In the following highlight we refer to a number of new advances in the field of Biotechnology that address issues relating to the synthesis of new antibiotics, new biocatalysts and matrices in biofilms.
متن کاملCombining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections
Many bacteria grow on surfaces forming biofilms. In this structure, they are well protected and often high dosages of antibiotics cannot clear infectious biofilms. The formation and stabilization of biofilms are mediated by diffusible autoinducers (e.g. N-acyl homoserine lactones, small peptides, furanosyl borate diester). Metabolites interfering with this process have been identified in plants...
متن کاملControl of Biofilm Formation: Antibiotics and Beyond.
Biofilm-associated bacteria are less sensitive to antibiotics than free-living (planktonic) cells. Furthermore, with variations in the concentration of antibiotics throughout a biofilm, microbial cells are often exposed to levels below inhibitory concentrations and may develop resistance. This, as well as the irresponsible use of antibiotics, leads to the selection of pathogens that are difficu...
متن کاملMetabolic Engineering: New Era in Pharmaceuticals
Natural products are a prime source for drug industry as their products are often used as drug or drug precursors. But, their extraction and synthesis in large amount are eminently difficult and a major challenge till date. So, for the production of steadily more amount of these drugs and drug precursors, researchers focused on the new metabolic engineering strategies [1]. Metabolic engineering...
متن کاملModular co-culture engineering, a new approach for metabolic engineering.
With the development of metabolic engineering, employment of a selected microbial host for accommodation of a designed biosynthetic pathway to produce a target compound has achieved tremendous success in the past several decades. Yet, increasing requirements for sophisticated microbial biosynthesis call for establishment and application of more advanced metabolic engineering methodologies. Rece...
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ژورنال
عنوان ژورنال: Microbial Biotechnology
سال: 2009
ISSN: 1751-7915
DOI: 10.1111/j.1751-7915.2009.00157.x